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Typically, the first method should be enough for disabling Skype from running automatically at startup.

Note: Signing out from Skype account will not delete your contacts, chats, or Skype account. Click on your profile picture icon at the top-left corner. To sign out of the Skype account, launch the Skype app. Next time, Skype won’t autorun on startup provided you log out before closing Windows. In that case, you can stop Skype from starting automatically by simply signing out of your account when you are done using it. Suppose you are using Skype for Windows 10 (application version 15 and above) that you installed from Microsoft Store. Let’s see how to achieve that in several ways.
